InterPro domain: IPR014842

General Information

  • Identifier IPR014842
  • Description Iron-regulated transcriptional activator AFT
  • Number of genes 20
  • Gene duplication stats Loading...
  • Associated GO terms GO:0036086   GO:0000981  

Abstract

AFT (activator of iron transcription) is an iron regulated transcriptional activator that regulates the expression of genes involved in iron homeostasis. This entry includes the paralogous pair of transcription factors AFT1 and AFT2 [ 1 , 2 ].


1. The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae. Yeast 13, 621-37
2. Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J. Biol. Chem. 278, 27636-43

Species distribution

Gene table