InterPro domain: IPR014816

General Information

  • Identifier IPR014816
  • Description tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14

Abstract

Gcd14, also known as Trm61, is the catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase [ 1 , 2 ], which is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA [ 3 ].


1. A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase. Nucleic Acids Res. 32, 465-76
2. The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A. 97, 5173-8
3. The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. Genes Dev. 12, 3650-62

Species distribution

Gene table