InterPro domain: IPR014812

General Information

  • Identifier IPR014812
  • Description Vacuolar protein sorting-associated protein 51
  • Number of genes 182
  • Gene duplication stats Loading...

Abstract

The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved in recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Ang2 or Vps67) is a subunit of VFT and interacts with the SNARE Tlg1 [ 1 ]. It is also part of the endosome-associated recycling protein (EARP) complex which is structurally related to GARP complex [ 2 ].


1. Vps51p links the VFT complex to the SNARE Tlg1p. J. Biol. Chem. 277, 48318-24
2. EARP is a multisubunit tethering complex involved in endocytic recycling. Nat. Cell Biol. 17, 639-50

Species distribution

Gene table