InterPro domain: IPR014811

ArgoL1 is a region found in argonaute [ 1 ] proteins. It normally co-occurs with BAG domain ( IPR003103 ) and Piwi domain ( IPR003165 ). It is a linker region between the N-terminal and the PAZ domains. It contains an alpha-helix packed against a three-stranded antiparallel beta-sheet with two long beta-strands (beta8 and beta9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with linker 2, L2, PAZ and ArgoN forms a compact global fold [ 2 ].

1. Structure and function of argonaute proteins. Structure 13, 1403-8
2. Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage. Mol. Cell 19, 405-19