InterPro domain: IPR014790

General Information

  • Identifier IPR014790
  • Description MutL, C-terminal, dimerisation
  • Number of genes 212
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005524   GO:0006298  

Abstract

MutL and MutS are key components of the DNA repair machinery that corrects replication errors [ 1 ]. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signalling complex for repair. The N-terminal region of MutL contains the ATPase domain and the C-terminal is involved in dimerisation [ 2 ].


1. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu. Rev. Biochem. 65, 101-33
2. Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair. EMBO J. 23, 4134-45

Species distribution

Gene table