InterPro domain: IPR014786
General Information
- Identifier IPR014786
- Description Anaphase-promoting complex subunit 2, C-terminal
- Number of genes 126
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Abstract
The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome [ 1 ].
This entry represents a domain found in the C terminus of APC subunit 2.
1. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell 133, 653-65
Species distribution
Gene table
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