InterPro domain: IPR014757

The many bacterial transcription regulation proteins which bind DNA through a 'helix-turn-helix' motif can be classified into subfamilies on the basis of sequence similarities. One of these subfamilies, called 'iclR', groups several proteins including:

• gylR, a possible activator protein for the gylABX glycerol operon in Streptomyces.

• iclR, the repressor of the acetate operon (also known as glyoxylate bypass operon) in Escherichia coli and Salmonella typhimurium.

These proteins have a Helix-Turn-Helix motif at the N terminus that is similar to that of other DNA-binding proteins [ 1 ]. This entry represents their C-terminal domain, which shares protein structural similarity with the GAF-like domain.

1. Characterization of kdgR, a gene of Erwinia chrysanthemi that regulates pectin degradation. Mol. Microbiol. 5, 2203-16