InterPro domain: IPR014718

This superfamily represents a domain with a distorted supersandwich structure consisting of 18 strands in two sheets, which probably functions to bind carbohydrates in enzymes that act on sugars. Domains with this structure occur in several protein families, including galactose mutarotase ( 5.1.3.3 ); domain 5 of beta-galactosidase ( 3.2.1.23 ); the central domain of hyaluronate lyase-like enzymes, such as chondroitinase AC ( 4.2.2.5 ), chrondroitin ABC lyase I, and hyaluronate lyase ( 4.2.2.1 ) itself [ 1 ]; and the N-terminal domain of bacterial glucoamylase ( 3.2.1.3 ) [ 2 ] and rhamnogalacturonate lyase ( 4.2.2.23 ).

1. Purification and characterization of hyaluronic acid from the mollusc bivalve Mytilus galloprovincialis. Biochimie 85, 619-25
2. Glucoamylase from Thermoanaerobacterium thermosaccharolyticum: Sequence studies and analysis of the macromolecular architecture of the enzyme. J. Gen. Appl. Microbiol. 44, 327-335