InterPro domain: IPR014717

An alpha+beta sandwich domain with a Ferredoxin-like fold can be found in the beta chain of the translation elongation factor EF1B [ 1 ], and in the ribosomal protein S6 from the small subunit [ 2 ].

Elongation factor EF1B (also known as EF-Ts or EF-1beta/gamma/delta) is a nucleotide exchange factor that is required to regenerate EF1A from its inactive form (EF1A-GDP) to its active form (EF1A-GTP). EF1A is then ready to interact with a new aminoacyl-tRNA to begin the cycle again. EF1B is more complex in eukaryotes than in bacteria, and can consist of three subunits: EF1B-alpha (or EF-1beta), EF1B-gamma (or EF-1gamma) and EF1B-beta (or EF-1delta) [ 3 ].

1. Structural basis for nucleotide exchange and competition with tRNA in the yeast elongation factor complex eEF1A:eEF1Balpha. Mol. Cell 6, 1261-6
2. Structure of the S15,S6,S18-rRNA complex: assembly of the 30S ribosome central domain. Science 288, 107-13
3. Structural studies of eukaryotic elongation factors. Cold Spring Harb. Symp. Quant. Biol. 66, 425-37