InterPro domain: IPR014551

Non-lysosomal glucosylceramidase, also known as beta-glucosidase 2 (GBA2) is an enzyme involved in an alternative catabolic pathway of glucosylceramide [ 1 ]. GBA2, has been characterised as a bile acid beta-glucosidase [ 2 ]. It is unrelated to other known glucosidases, but it has homologues among bacteria and archaea [ 3 ].

1. Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2. J. Biol. Chem. 282, 1305-12
2. Molecular cloning and expression of human bile acid beta-glucosidase. J. Biol. Chem. 276, 37929-33
3. A new archaeal beta-glycosidase from Sulfolobus solfataricus: seeding a novel retaining beta-glycan-specific glycoside hydrolase family along with the human non-lysosomal glucosylceramidase GBA2. J. Biol. Chem. 285, 20691-703