InterPro domain: IPR014222

This entry contains subunit II (CoxB) of cytochrome c oxidase. Cytochrome c oxidase is the terminal electron acceptor of mitochondria (and one of several possible acceptors in prokaryotes) in the electron transport chain of aerobic respiration. The enzyme couples the oxidation of reduced cytochrome c to the reduction of molecular oxygen to water. This process results in the pumping of four protons across the membrane that are used in the proton gradient powered synthesis of ATP. The oxidase contains two haem A cofactors and three copper atoms as well as other bound ions [ 1 ].

1. Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment. Proc. Natl. Acad. Sci. U.S.A. 94, 10547-53