InterPro domain: IPR013963

General Information

  • Identifier IPR013963
  • Description DASH complex subunit Dad2

Abstract

The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [ 1 ]. In Saccharomyces cerevisiae (Baker's yeast) DASH forms both rings and spiral structures on microtubules in vitro [ 2 , 3 ].


1. The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev. 16, 183-97
2. The yeast DASH complex forms closed rings on microtubules. Nat. Struct. Mol. Biol. 12, 138-43
3. Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol. Cell 17, 277-90

Species distribution

Gene table