InterPro domain: IPR013955

General Information

  • Identifier IPR013955
  • Description Replication factor A, C-terminal
  • Number of genes 2555
  • Gene duplication stats Loading...

Abstract

Replication factor A (RP-A) binds and subsequently stabilises single-stranded DNA intermediates and thus prevents complementary DNA from reannealing. It also plays an essential role in several cellular processes in DNA metabolism including replication, recombination and repair of DNA [ 1 ]. Replication factor-A protein is also known as Replication protein A 70kDa DNA-binding subunit.

This entry is found at the C terminus of Replication factor A.


1. Study of interaction of human replication factor A with DNA using new photoreactive analogs of dTTP. Biochemistry Mosc. 65, 160-3

Species distribution

Gene table