InterPro domain: IPR013950

General Information

  • Identifier IPR013950
  • Description Kinetochore Mis14/Nsl1
  • Number of genes 1
  • Gene duplication stats Loading...
  • Associated GO terms GO:0000070   GO:0000776  

Abstract

This entry includes Mis14 from S. pombe, Nsl1 from S. cerevisiae and Nsl1 homologues from animals. MIs14 is a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle [ 1 ]. Nsl1 is an essential component of the kinetochore MIND complex, which is required for the spindle checkpoint and kinetochore integrity [ 2 ].


1. Mis16 and Mis18 are required for CENP-A loading and histone deacetylation at centromeres. Cell 118, 715-29
2. Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev. 17, 2902-21

Species distribution

Gene table