InterPro domain: IPR013906
General Information
- Identifier IPR013906
- Description Eukaryotic translation initiation factor 3 subunit J
- Number of genes 222
- Gene duplication stats Loading...
- Associated GO terms GO:0003743 GO:0005737 GO:0005852
Abstract
This shows protein subunits of the eukaryotic translation initiation factor 3 J (eIF3j). It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome [ 1 , 2 ]. In Saccharomyces cerevisiae, eIF3j has been shown to be required for processing of 20S pre-rRNA and binds to 18S rRNA and eIF3 subunits Rpg1p and Prt1p [ 3 ].
1. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. J. Biol. Chem. 279, 8946-56
2. Conservation and diversity of eukaryotic translation initiation factor eIF3. J. Biol. Chem. 272, 1101-9
3. A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met. EMBO J. 20, 2954-65