InterPro domain: IPR013905

The Lethal giant larvae (Lgl) tumour suppressor protein is conserved from yeast to mammals. The Lgl protein functions in cell polarity, at least in part, by regulating SNARE-mediated membrane delivery events at the cell surface [ 1 ]. The N-terminal half of Lgl members contains WD40 repeats (see IPR001680 ), while the C-terminal half appears specific to the protein [ 2 ].

1. Structurally conserved interaction of Lgl family with SNAREs is critical to their cellular function. Curr. Biol. 15, 1136-42