InterPro domain: IPR013896

This ubiquitin-associated (UBA) domain is found in yeast carbon catabolite-derepressing protein kinases (Snf1) and similar proteins from fungi. Mutations in this domain significantly alter SNF1 kinase activation and biological activity [ 1 ].

Snf1, also called yeast adenosine monophosphate (AMP)-activated protein kinase (AMPK), is a global regulator of carbon metabolism in the yeast Saccharomyces cerevisiae [ 2 , 3 ]. Snf1 is involved in the cellular responses to nutrient stress, as well as other environmental stresses [ 4 , 5 , 6 ].

1. The SNF1 Kinase Ubiquitin-associated Domain Restrains Its Activation, Activity, and the Yeast Life Span. J. Biol. Chem. 290, 15393-404
2. SNF1/AMPK pathways in yeast. Front. Biosci. 13, 2408-20
3. Glucose regulates protein interactions within the yeast SNF1 protein kinase complex. Genes Dev. 10, 3105-15
4. Regulation of snf1 protein kinase in response to environmental stress. J. Biol. Chem. 282, 16838-45
5. The AMPK family member Snf1 protects Saccharomyces cerevisiae cells upon glutathione oxidation. PLoS ONE 8, e58283
6. Snf1 protein kinase: a key player in the response to cellular stress in yeast. Biochem. Soc. Trans. 31, 178-81