InterPro domain: IPR013882
General Information
- Identifier IPR013882
- Description DNA endonuclease Ctp1, C-terminal
- Number of genes 68
- Gene duplication stats Loading...
- Associated GO terms GO:0006281 GO:0004519
Abstract
This entry represents the C-terminal domain of the fission yeast Ctip protein. Proteins containing this domain include DNA endonuclease RBBP8 from animals and protein gamma response 1 (GR1) from Arabidopsis [ 1 ]. However, this entry does not include Sae2 from Saccharomyces cerevisiae.
RBBP8 is an endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends [ 2 ]. Ctp1 is an endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends [ 3 ].
1. Molecular cloning and developmental expression of AtGR1, a new growth-related Arabidopsis gene strongly induced by ionizing radiation. Radiat. Res. 154, 355-64
2. Human CtIP promotes DNA end resection. Nature 450, 509-14
3. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol. Cell 28, 134-46