InterPro domain: IPR013880

In yeast, Yos1 is a subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex [ 1 ].

This entry also includes animal IER3IP1 (immediate Early Response 3 Interacting Protein 1), which is localized to the endoplasmic reticulum. Mutations in the IER3IP1 gene cause permanent neonatal diabetes mellitus in human [ 2 ].

1. Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Mol. Biol. Cell 16, 1673-83
2. IER3IP1 deficiency leads to increased β-cell death and decreased β-cell proliferation. Oncotarget 8, 56768-56779