InterPro domain: IPR013877

This entry contains a number of protein families with apparently unrelated functions. The yeast YAP binding proteins are stress response and redox homeostasis proteins, induced by hydrogen peroxide or induced in response to alkylating agent methyl methanesulphonate (MMS) [ 1 , 2 ]. Aberrant root formation protein 4 (ALF4) of Arabidopsis thaliana (Mouse-ear cress),is required for the initiation of lateral roots independent from auxin signalling. It may also function in maintaining the pericycle in the mitotically competent state needed for lateral root formation [ 3 ]. Glomulin (FAP68) is essential for normal development of the vasculature and may represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12 [ 4 , 5 ].

1. Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor. J. Biol. Chem. 278, 30896-904
2. Global response of Saccharomyces cerevisiae to an alkylating agent. Proc. Natl. Acad. Sci. U.S.A. 96, 1486-91
3. Arabidopsis ALF4 encodes a nuclear-localized protein required for lateral root formation. Plant J. 37, 340-53
4. Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor. J. Biol. Chem. 276, 46632-8
5. The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis. Proc. Natl. Acad. Sci. U.S.A. 100, 2444-9