InterPro domain: IPR013876

General Information

  • Identifier IPR013876
  • Description TFIIH p62 subunit, N-terminal
  • Number of genes 74
  • Gene duplication stats Loading...

Abstract

The N-terminal region of the TFIIH basal transcription factor complex p62 subunit (BTF2-p62) forms an interaction with the 3' endonuclease XPG, which is essential for activity. The 3' endonuclease XPG is a major component of the nucleotide excision repair machinery. The structure of the N-terminal region reveals that it adopts a pleckstrin homology (PH) fold [ 1 , 2 ].


1. TFIIH contains a PH domain involved in DNA nucleotide excision repair. Nat. Struct. Mol. Biol. 11, 616-22
2. NMR structure of the amino-terminal domain from the Tfb1 subunit of TFIIH and characterization of its phosphoinositide and VP16 binding sites. Biochemistry 44, 7678-86

Species distribution

Gene table