InterPro domain: IPR013857

Mitochondrial complex I intermediate-associated protein 30 (CIA30) is present in human and mouse, and also in Schizosaccharomyces pombe (Fission yeast) which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits. This means it is not directly involved in oxidative phosphorylation [ 1 , 2 ]. In Drosophila it has been shown to be a chaperone required for assembly complex I [ 3 ].

1. CIA30 complex I assembly factor: a candidate for human complex I deficiency? Hum. Genet. 110, 264-70
2. Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction. J. Mol. Biol. 226, 1051-72
3. Expression of yeast NDI1 rescues a Drosophila complex I assembly defect. PLoS ONE 7, e50644