InterPro domain: IPR013842
General Information
- Identifier IPR013842
- Description GTP-binding protein LepA, C-terminal
- Number of genes 229
- Gene duplication stats Loading...
Abstract
The elongation factor 4 (LepA or GUF1 in Saccaromyces) is a GTP-binding membrane protein related to EF-G and EF-Tu. LepA is a noncanonical GTPase that has an unknown function. It is highly conserved and present in bacteria, mitochondria, and chloroplasts [ 1 ].
LepA contains domains that are homologous to EF-G domain I, II, III, V. However, it also contains a C-terminal domain (CTD) that is not homologous to any region in EF-G. This entry represents the unique C-terminal region of LepA [ 2 ]. The CTD of LepA may play a primary role in back translocation by providing additional binding interactions with a back-translocated tRNA [ 3 ].
1. Taking a Step Back from Back-Translocation: an Integrative View of LepA/EF4's Cellular Function. Mol. Cell. Biol. 37
2. The structure of LepA, the ribosomal back translocase. Proc. Natl. Acad. Sci. U.S.A. 105, 4673-8