InterPro domain: IPR013802

General Information

  • Identifier IPR013802
  • Description Formiminotransferase, C-terminal subdomain
  • Number of genes 127
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016740   GO:0005542  

Abstract

The formiminotransferase (FT) domain of formiminotransferase-cyclodeaminase (FTCD) forms a homodimer, with each protomer being comprised of two subdomains. The formiminotransferase domain has an N-terminal subdomain that is made up of a six-stranded mixed beta-pleated sheet and five alpha helices, which are arranged on the external surface of the beta sheet. This, in turn, faces the beta-sheet of the C-terminal subdomain to form a double beta-sheet layer. The two subdomains are separated by a short linker sequence, which is not thought to be any more flexible than the remainder of the molecule. The substrate is predicted to form a number of contacts with residues found in both the N-terminal and C-terminal subdomains [ 1 ]. In humans, deficiency of this enzyme results in a disease phenotype [ 2 ].

This entry represents the C-terminal subdomain of the formiminotransferase domain.


1. The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme. Structure 8, 35-46
2. The molecular basis of glutamate formiminotransferase deficiency. Hum. Mutat. 22, 67-73

Species distribution

Gene table

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