InterPro domain: IPR013740

This redoxin domain is found in peroxiredoxin, thioredoxin and glutaredoxin proteins. Peroxiredoxins (Prxs) constitute a family of thiol peroxidases that reduce hydrogen peroxide, peroxinitrite, and hydroperoxides using a strictly conserved cysteine [ 1 , 2 ]. Chloroplast thioredoxin systems in plants regulate the enzymes involved in photosynthetic carbon assimilation [ 3 ]. It is thought that redoxins have a large role to play in anti-oxidant defence. Cadmium-sensitive proteins are also regulated via thioredoxin and glutaredoxin thiol redox systems [ 4 ].

1. Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism. Biochemistry 44, 1755-67
2. The Crystal Structure of Peroxiredoxin Asp f3 Provides Mechanistic Insight into Oxidative Stress Resistance and Virulence of Aspergillus fumigatus. Sci Rep 6, 33396
3. Glutaredoxins and thioredoxins in plants. Biochim. Biophys. Acta 1783, 589-600
4. Cadmium response and redoxin targets in Chlamydomonas reinhardtii: a proteomic approach. Photosyn. Res. 89, 201-11