InterPro domain: IPR013730

This entry include proteins from the FYV7 and the TAP26 families [ 1 ].

FYV7 is involved in the processing of 20S pre-rRNA during the maturation of SSU-rRNA from tricistronic RNA transcripts (SSU-rRNA, 5.8S rRNA, LSU-rRNA). The SSU (small subunit) processome is required for production of the small ribosomal subunit RNA, the 18S rRNA [ 2 ]. Fyv7 may also be required for survival upon K1 Killer toxin exposure.

Thyroid transcription factor 1-associated protein 26 (TAP26, also known as BR22) is a component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). It enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities [ 3 , 4 ].

1. A panoramic view of yeast noncoding RNA processing. Cell 113, 919-33
2. Components of an interdependent unit within the SSU processome regulate and mediate its activity. Mol. Cell. Biol. 22, 7258-67
3. BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26), is expressed in human lung cells. Eur. Respir. J. 22, 28-34
4. The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells. Biochem. Biophys. Res. Commun. 344, 484-90