InterPro domain: IPR013725

General Information

  • Identifier IPR013725
  • Description DNA replication factor RFC1, C-terminal

Abstract

This is the C-terminal domain of replication factor C, RFC1. RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo [ 1 , 2 ].


1. Contrasting effects of Elg1-RFC and Ctf18-RFC inactivation in the absence of fully functional RFC in fission yeast. Nucleic Acids Res. 33, 4078-89
2. Deletion analysis of the large subunit p140 in human replication factor C reveals regions required for complex formation and replication activities. J. Biol. Chem. 272, 10058-64

Species distribution

Gene table