InterPro domain: IPR013709

General Information

  • Identifier IPR013709
  • Description 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain
  • Number of genes 205
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003852   GO:0009098  

Abstract

This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway [ 1 ]. This domain, is an internally duplicated structure with a novel fold [ 2 ]. It comprises two similar units that are arranged such that the two helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich [ 2 ].


1. Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 101, 8295-300

Species distribution

Gene table