InterPro domain: IPR013708
General Information
- Identifier IPR013708
- Description Shikimate dehydrogenase substrate binding, N-terminal
- Number of genes 333
- Gene duplication stats Loading...
- Associated GO terms GO:0004764
Abstract
This domain is the substrate binding domain of shikimate dehydrogenase [ 1 ]. Shikimate dehydrogenase catalyses the fourth step of the mycobacterial Shikimate pathway, which results in the biosynthesis of chorismate. Chorismate is a precursor of aromatic amino acids, naphthoquinones, menaquinones and mycobactins [ 2 , 3 ]. This pathway is an important target for antibacterial agents, especially against Mycobacterium tuberculosis, since it does not occur in mammals.
1. Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae. J. Biol. Chem. 280, 17101-8
2. Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis. Proteins 72, 720-30
3. Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities. J. Biol. Chem. 278, 19463-72