InterPro domain: IPR013637
General Information
- Identifier IPR013637
- Description Lysine-specific demethylase-like domain
- Number of genes 108
- Gene duplication stats Loading...
Abstract
This domain is found in the central region of lysine-specific demethylases, which are nuclear proteins that may have a role in DNA-binding and transcription, and are associated with malignant cancer phenotypes [ 1 ]. The domain is also found in various other Jumonji/ARID domain-containing proteins (see IPR003347 , IPR001606 ).
1. A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J. Biol. Chem. 274, 15633-45
Species distribution
Gene table
Loading...