InterPro domain: IPR013637

General Information

  • Identifier IPR013637
  • Description Lysine-specific demethylase-like domain
  • Number of genes 108
  • Gene duplication stats Loading...

Abstract

This domain is found in the central region of lysine-specific demethylases, which are nuclear proteins that may have a role in DNA-binding and transcription, and are associated with malignant cancer phenotypes [ 1 ]. The domain is also found in various other Jumonji/ARID domain-containing proteins (see IPR003347 , IPR001606 ).


1. A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J. Biol. Chem. 274, 15633-45

Species distribution

Gene table