InterPro domain: IPR013328

This superfamily represents a multi-helical domain found in several NAD or NADP-utilizing dehydrogenases, including 6-phosphogluconate dehydrogenase [ 1 ], classes I and II ketol-acid reductoisomerases [ 2 ], L-3-hydroxyacyl CoA dehydrogenase [ 3 ], UDP-glucose dehydrogenase [ 4 ], glycerol-3-phosphate dehydrogenase [ 5 ], ketopantoate reductase [ 6 ], N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [ 7 ], and mannitol 2-dehydrogenase [ 8 ]. This domain is often found in the C-terminal region of the protein.

1. Importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase. J. Biol. Chem. 281, 25568-76
2. The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. Protein Sci. 14, 3089-100
3. Glutamate 170 of human l-3-hydroxyacyl-CoA dehydrogenase is required for proper orientation of the catalytic histidine and structural integrity of the enzyme. J. Biol. Chem. 276, 36718-26
4. Identification of a UDP-glucose-binding site of human UDP-glucose dehydrogenase by photoaffinity labeling and cassette mutagenesis. Bioconjug. Chem. 16, 710-6
5. Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1). J. Mol. Biol. 357, 858-69
6. The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound. Biochemistry 44, 8930-9
7. Crystal structure and active site location of N-(1-D-carboxylethyl)-L-norvaline dehydrogenase. Nat. Struct. Biol. 5, 593-601
8. NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum. J. Biol. Chem. 281, 16354-60