InterPro domain: IPR013261

General Information

  • Identifier IPR013261
  • Description Mitochondrial import inner membrane translocase subunit Tim21
  • Number of genes 145
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005744   GO:0030150  

Abstract

Tim21 is an essential component of the TIM23 complex, which mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Tim21 is required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix [ 1 , 2 ].


1. Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-29
2. Role of Tim21 in mitochondrial translocation contact sites. J. Biol. Chem. 280, 23437-40

Species distribution

Gene table