InterPro domain: IPR013255
General Information
- Identifier IPR013255
- Description Chromosome segregation protein Spc25, C-terminal
- Number of genes 152
- Gene duplication stats Loading...
- Associated GO terms GO:0031262 GO:0007059
Abstract
This entry represents the C-terminal domain of Spc25 [ 1 ].
The Ndc80 complex is a conserved outer kinetochore protein complex consisting of Ndc80 (Hec1), Nuf2, Spc24 and Spc25. The Ndc80 complex is required for chromosome segregation and spindle checkpoint activity [ 2 , 3 , 4 ].
1. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr. Biol. 14, 131-7
2. Purification and characterisation of the fission yeast Ndc80 complex. Protein Expr Purif 135, 61-69
3. The Ndc80 complex: hub of kinetochore activity. FEBS Lett. 581, 2862-9
4. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. J. Cell Biol. 152, 349-60