InterPro domain: IPR013244

This entry represents a Sec39 domain, which can be found in yeast Sec39, human NBAS (neuroblastoma-amplified sequence) [ 1 ] and Arabidopsis MIP2 (MAG2-INTERACTING PROTEIN 2) [ 2 ]. They may be involved in Golgi-to-ER transport.

Sec39 was originally identified as a protein involved in ER-Golgi transport in a large scale promoter shut down analysis of essential yeast genes [ 3 ]. A subsequent study found that Sec39p (Dsl3p) is required for Golgi-ER retrograde transport and is part of a very stable protein complex that also includes Dsl1p (in mammals ZW10), Tip20p (Rint-1) and the ER localized Q-SNARE proteins Ufe1p (syntaxin-18), Sec20p and Use1p [ 4 ]. This was confirmed in a genome-wide analysis of protein complexes [ 4 ].

1. The neuroblastoma amplified gene, NAG: genomic structure and characterisation of the 7.3 kb transcript predominantly expressed in neuroblastoma. Gene 307, 1-11
2. MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana. Plant J. 76, 781-91
3. Exploration of essential gene functions via titratable promoter alleles. Cell 118, 31-44
4. Proteome survey reveals modularity of the yeast cell machinery. Nature 440, 631-6