InterPro domain: IPR013240

General Information

  • Identifier IPR013240
  • Description DNA-directed RNA polymerase I, subunit RPA34.5
  • Number of genes 3
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006360  

Abstract

This is a family of proteins conserved from yeasts to human. Subunit A34.5 of RNA polymerase I is a non-essential subunit which is thought to help Pol I overcome topological constraints imposed on ribosomal DNA during the process of transcription [ 1 ]. It forms a heterodimer with RPA49 which stimulates transcript elongation by Pol I [ 2 ].


1. A34.5, a nonessential component of yeast RNA polymerase I, cooperates with subunit A14 and DNA topoisomerase I to produce a functional rRNA synthesis machine. Mol. Cell. Biol. 17, 1787-95
2. RNA polymerase I structure and transcription regulation. Nature 502, 650-5

Species distribution

Gene table