InterPro domain: IPR013177

This domain of unknown function is found at the C-terminal end of mitochondrial mRNA-processing protein COX24 from yeast (also known as Mitochondrial small ribosomal subunit protein mS38), which is involved in the splicing of the COX1 mRNA [ 1 ]. COX24 is a component of the mitochondrial ribosome (mitoribosome), responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane [ 2 , 3 ]. This domain is also found in COX24 mammalian homologue aurora-A kinase interacting protein (AIP) [ 4 ]. This entry also includes uncharacterised proteins from bacteria.

1. COX24 codes for a mitochondrial protein required for processing of the COX1 transcript. J. Biol. Chem. 281, 3743-51
2. Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography. Nat Commun 6, 6019
3. The structure of the yeast mitochondrial ribosome. Science 355, 528-531
4. Aurora-A kinase interacting protein 1 (AURKAIP1) promotes Aurora-A degradation through an alternative ubiquitin-independent pathway. Biochem. J. 403, 119-27