InterPro domain: IPR013176

General Information

  • Identifier IPR013176
  • Description Vacuolar fusion protein Ccz1
  • Number of genes 136
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016192   GO:0035658  

Abstract

This entry includes the fungal vacuolar fusion protein Ccz1 which forms a complex with Mon1. The CCZ1-MON1 complex acts where vesicles fuse with the vacuole and is required in several vacuolar delivery pathways including autophagy, pexophagy and endocytosis as well cytoplasm to vacuole transport [ 1 , 2 , 3 ]. Ccz1 interacts with a GTPase during fusion [ 4 ].


1. The Ccz1-Mon1 protein complex is required for the late step of multiple vacuole delivery pathways. J. Biol. Chem. 277, 47917-27
2. Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J. Cell Biol. 163, 973-85
3. Multiple functions of the vacuolar sorting protein Ccz1p in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 329, 197-204
4. The Ccz1 protein interacts with Ypt7 GTPase during fusion of multiple transport intermediates with the vacuole in S. cerevisiae. J. Cell. Sci. 114, 3137-45

Species distribution

Gene table

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