InterPro domain: IPR013120

This family represents the C-terminal NAD-binding region of the fatty acyl-coenzyme A reductases (FARs) from Arabidopsis and animals. FARs catalyze the reduction of fatty acyl-CoA to fatty alcohols [ 1 , 2 ].

Proteins containing this domain also include non-ribosomal peptide synthetases and non-reducing polyketide synthases from Aspergillaceae. Non-ribosomal peptide synthetases are part of the gene cluster that mediates the biosynthesis of the lipopeptide antibiotics leucinostatins [ 3 ]. Non-reducing polyketide synthases are involved in the secondary metabolite biosynthesis [ 4 ].

Proteins containing this domain also include L-2-aminoadipate reductase from yeasts [ 5 ] and carboxylic acid reductase (car) from bacteria [ 6 ].

1. Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition. Plant Physiol. 153, 1539-54
2. Topogenesis and homeostasis of fatty acyl-CoA reductase 1. J. Biol. Chem. 288, 34588-98
3. Biosynthesis of Antibiotic Leucinostatins in Bio-control Fungus Purpureocillium lilacinum and Their Inhibition on Phytophthora Revealed by Genome Mining. PLoS Pathog. 12, e1005685
4. Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans. J. Am. Chem. Soc. 134, 8212-21
5. Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5. Biochemistry 38, 6171-7
6. Reduction of carboxylic acids by Nocardia aldehyde oxidoreductase requires a phosphopantetheinylated enzyme. J. Biol. Chem. 282, 478-85