InterPro domain: IPR013109

NO66 (also known as ribosomal oxygenase 1) is a bifunctional enzyme, acting as a lysine-specific demethylase and a histidyl-hydroxylase. NO66 specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. It acts as a regulator of osteoblast differentiation and may also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region [ 1 , 2 , 3 ]. MYC-induced nuclear antigen is involved in cellular proliferation [ 4 , 5 , 6 ]. It may be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles [ 7 ].

1. NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin. Mol. Biol. Cell 15, 1816-32
2. Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J. 29, 68-79
3. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. Nat. Chem. Biol. 8, 960-962
4. A novel myc target gene, mina53, that is involved in cell proliferation. J. Biol. Chem. 277, 35450-9
5. Increased expression of a Myc target gene Mina53 in human colon cancer. Am. J. Pathol. 164, 205-16
6. Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma. Clin. Cancer Res. 10, 7347-56
7. Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66. Eur. J. Cell Biol. 84, 279-94