InterPro domain: IPR013105

The tetratrico peptide repeat (TPR) is a structural motif present in a wide range of proteins [ 1 , 2 , 3 ]. It mediates protein-protein interactions and the assembly of multiprotein complexes [ 4 ]. The TPR motif consists of 3-16 tandem-repeats of 34 amino acids residues, although individual TPR motifs can be dispersed in the protein sequence. Sequence alignment of the TPR domains reveals a consensus sequence defined by a pattern of small and large amino acids. TPR motifs have been identified in various different organisms, ranging from bacteria to humans. Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding [ 5 ].

This repeat includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by IPR001440 .

1. Tetratrico peptide repeat interactions: to TPR or not to TPR? Trends Biochem. Sci. 20, 257-9
2. The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. EMBO J. 17, 1192-9
3. The TPR snap helix: a novel protein repeat motif from mitosis to transcription. Trends Biochem. Sci. 16, 173-7
4. TPR proteins: the versatile helix. Trends Biochem. Sci. 28, 655-62
5. Structural and functional discussion of the tetra-trico-peptide repeat, a protein interaction module. Structure 20, 397-405