InterPro domain: IPR012957
General Information
- Identifier IPR012957
- Description CHD, C-terminal 2
- Number of genes 35
- Gene duplication stats Loading...
Abstract
This entry represents the C-terminal domain of CHD (Chromodomain, Helicase, DNA-binding) proteins. CHD3 and CHD4 belong to the class II subfamily of CHD ATPases, and each is present as a core catalytic subunit in separate NuRD complexes, which regulate chromatin organisation and gene transcription [ 1 ]. CHD5 forms a NuRD-type chromatin remodeling complex and acts as a tumour suppressor [ 2 ].
There are nine members of the Chromodomain, Helicase, DNA-binding (CHD) family. They are characterised by two chromodomains arranged in tandem, N-terminal to the ATPase/helicase domain. Chromodomains are comprised of a beta-sheet folded against an alpha-helix that collectively mediates binding to methyl-lysine residues [ 3 ].
1. The NuRD architecture. Cell. Mol. Life Sci. 70, 3513-24
2. Role of CHD5 in human cancers: 10 years later. Cancer Res. 74, 652-8
3. CHD chromatin remodelling enzymes and the DNA damage response. Mutat. Res. 750, 31-44