InterPro domain: IPR012951

This domain is found in the berberine bridge and berberine bridge-like enzymes, flavoproteins which have an unusual bicovalent attachment of the FAD cofactor that are involved in the biosynthesis of numerous isoquinoline alkaloids. They catalyse the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine [ 1 , 2 ]. This domain is found in many flavoproteins mainly from bacteria, fungi and plants.

1. Molecular characterization of berberine bridge enzyme genes from opium poppy. Plant Physiol. 112, 1669-77
2. Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism. J Biol Chem 290, 18770-81