InterPro domain: IPR012948

This domain is the central domain of AARP2 (asparagine and aspartate rich protein 2). It is weakly similar to the GTP-binding domain of elongation factor TU [ 1 ]. PfAARP2 is an antigen from Plasmodium falciparum of 150kDa, which is encoded by a unique gene on chromosome 1 [ 2 ]. The central region of Pfaarp2 contains blocks of repetitions encoding asparagine and aspartate residues.

1. Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. Bioessays 26, 567-81
2. Plasmodium falciparum asparagine and aspartate rich protein 2 is an evolutionary conserved protein whose repeats identify a new family of parasite antigens. Mol. Biochem. Parasitol. 87, 169-81