InterPro domain: IPR012945

This domain is found in tubulin-binding cofactor C (or tubulin-specific chaperone C) (TBCC) and in protein XRP2. TBCC is a folding cofactor that participates in tubulin biogenesis along with the other tubulin folding cofactors A (TBCA), B (TBCB), E (TBCE) and D (TBCD), as well as the GTP-binding protein Arl2 [ 1 , 2 ]. XRP2 is a GTPase-activating protein (GAP) involved in intracellular trafficking [ 3 ].

1. Role of cofactors B (TBCB) and E (TBCE) in tubulin heterodimer dissociation. Exp. Cell Res. 313, 425-36
2. Functional analysis of the tubulin-folding cofactor C in Arabidopsis thaliana. Curr. Biol. 12, 1519-23
3. The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat. Struct. Mol. Biol. 15, 373-80