InterPro domain: IPR012941
General Information
- Identifier IPR012941
- Description Phenol hydroxylase, C-terminal dimerisation domain
- Number of genes 2
- Gene duplication stats Loading...
Abstract
Phenol hydroxylase is a homodimer which hydroxylates phenol to catechol, or similar products. The enzyme is comprised of three domains. The first two domains form the active site. The third domain, this domain, is involved in forming the dimerisation interface. The domain adopts a thioredoxin-like fold [ 1 ]. Protein containing this domain also include 3-hydroxybenzoate 4-monooxygenase from Comamonas testosteroni [ 2 ].
1. The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis. Structure 6, 605-17
2. Examination and expansion of the substrate range of m-hydroxybenzoate hydroxylase. Biochem. Biophys. Res. Commun. 371, 149-53