InterPro domain: IPR012929

This domain is found in a number of proteins, including TPR protein ( P12270 ) and yeast myosin-like protein 1 (MLP1, Q02455 ). These proteins share a number of features; for example, they have coiled-coil regions and are associated with nuclear pores [ 1 , 2 , 3 ]. TPR is thought to be a component of nuclear pore complex- attached intranuclear filaments [ 4 ], and is implicated in nuclear protein import [ 4 ]. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerisation of kinase domains or by targeting these kinases to the nuclear pore complex [ 4 ]. Mlp1 acts as a docking platform for for heterogeneous nuclear ribonucleoproteins that are required for mRNA export [ 4 ].

1. Identification of protein p270/Tpr as a constitutive component of the nuclear pore complex-attached intranuclear filaments. J. Cell Biol. 136, 515-29
2. Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. J. Cell Biol. 127, 1515-26
3. Proteins connecting the nuclear pore complex with the nuclear interior. J. Cell Biol. 144, 839-55
4. The C-terminal domain of myosin-like protein 1 (Mlp1p) is a docking site for heterogeneous nuclear ribonucleoproteins that are required for mRNA export. Proc. Natl. Acad. Sci. U.S.A. 100, 1010-5