InterPro domain: IPR012916

This domain contains sequences that are similar to the N-terminal region of Red protein ( Q13123 ). This and related proteins contain a RED repeat which consists of a number of RE and RD sequence elements [ 1 ]. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region [ 2 ], suggesting that these proteins are expressed in the nucleus [ 2 ]. Protein RED (also known as IK) is found in the nucleus and is a component of the spliceosome [ 2 ]. It is also associated with the spindle pole where it co-localizes with and interacts with the spindle assembly checkpoint protein MAD1 during metaphase and anaphase. Depletion of RED shortens the mitotic cycle and MAD1 is incorrectly localized [ 3 ].

1. Isolation, sequencing and expression of RED, a novel human gene encoding an acidic-basic dipeptide repeat. Gene 230, 145-54
2. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell 170, 701-713.e11
3. RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint. J. Biol. Chem. 287, 11704-16