InterPro domain: IPR012908

General Information

  • Identifier IPR012908
  • Description GPI inositol-deacylase PGAP1-like
  • Number of genes 202
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016788  

Abstract

The sequences found in this family are similar to PGAP1 ( Q765A7 ). This is an endoplasmic reticulum membrane protein with a catalytic serine-containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important not only for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body but also for efficient degradation of misfolded GPI-anchored proteins in the ER [ 1 , 2 ].


1. Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. J. Biol. Chem. 279, 14256-63
2. Hepatic adenylate cyclase and phosphodiesterase activity during acute ethionine intoxication. Exp. Mol. Pathol. 40, 122-34

Species distribution

Gene table

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