InterPro domain: IPR012904
General Information
- Identifier IPR012904
- Description 8-oxoguanine DNA glycosylase, N-terminal
- Number of genes 108
- Gene duplication stats Loading...
- Associated GO terms GO:0006289 GO:0003684 GO:0008534
Abstract
The presence of 8-oxoguanine residues in DNA can give rise to G-C to T-A transversion mutations. This enzyme is found in archaeal, bacterial and eukaryotic species, and is specifically responsible for the process which leads to the removal of 8-oxoguanine residues. It has DNA glycosylase activity ( 3.2.2.23 ) and DNA lyase activity ( 4.2.99.18 ) [ 1 ]. The region featured in this family is the N-terminal domain, which is organised into a single copy of a TBP-like fold. The domain contributes residues to the 8-oxoguanine binding pocket [ 2 ].
1. Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA. Nature 403, 859-66
2. Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase. J. Mol. Biol. 317, 171-7