InterPro domain: IPR012875

General Information

  • Identifier IPR012875
  • Description Succinate dehydrogenase assembly factor 4
  • Number of genes 111
  • Gene duplication stats Loading...

Abstract

This entry includes SDHF4 from animals, Sdh8 from budding yeasts and some uncharacterised proteins from bacteria. Sdh8 is required for assembly of succinate dehydrogenase (SDH). It interacts with the catalytic Sdh1 subunit in the mitochondrial matrix, facilitating its association with Sdh2 and the subsequent assembly of the SDH holocomplex [ 1 ].


1. SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab. 20, 241-52

Species distribution

Gene table